OCEDP Research Projects

Biomarker Devices

Rapid measurment of biomarkers in patient samples is a major target for OCEDP research.

In collaboration with Dr. Jian-Ping Wang (Department of Electric Engineering at the University of Minnesota), Dr. Todd Klein, and other members of Dr. Wang’s research team, we developed benchtop and handheld Giant Magnetoresistive (GMR) biosensing systems that have the potential to serve as platforms for detecting a wide variety of protein biomarkers for human diseases, including ovarian cancer.  System development included spintronic and nanomagnetic materials, biomolecular chemistry, electronic circuitry, analog and digital signal processing, firmware programming, user interface programming on both PC and Android smartphone, communications over both USB and Bluetooth, and mechanical integration.  We demonstrated that the benchtop GMR biosensing system can be developed into an assay to detect ovarian cancer biomarkers. The prototype system delivered the required performance in terms of high-sensitivity multiplex assays in a portable format with enough flexibility to serve as a platform for ovarian cancer. We achieved multiplex detection of three well known biomarkers for ovarian cancer:  cancer antigen 125 (CA125 II), human epididymis protein 4 (HE4), and interleukin 6 (IL6).

 

Dr. Amy Skubitz and Dr. Jian-Ping Wang were joint senior authors of the manuscript entitled, “Development of a multiplexed giant magnetoresistive biosensor array prototype to quantify ovarian cancer biomarkers” which was accepted for publication in Biosensors and Bioelectronics.  The research in this manuscript is a culmination of a Pilot Project funded by the Department of Defense Ovarian Cancer Research Program which provided salary support for Dr. Wang’s graduate student, Todd Klein, and OCEDP’s Dr. Kristin Boylan. 

The manuscript is now available online here.

A team lead by Dr. Jian-Ping Wang with the assistance of OCEDP Director, Dr. Amy Skubitz, participated in the Nokia Sensing X Challenge to develop a low-cost, portable biosensing system. View the video below for more information, and see the team here

NSXC Team Z Lab Golden Gopher Magnetic Biosensing

Research Projects

Meet the Team

Facilities at UMN

Facilities at UMN

Research Funding Support

Research Funding Support

Funding for the OCEDP has been provided by:

National Institutes of Health / National Cancer Institute

Department of Defense Congressionally Directed Medical Research Programs

Minnesota Ovarian Cancer Alliance 

Cancurables Foundation

Charlene's Light 

University of Minnesota

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Contact Us

Contact Us

Contact the Director:

Amy P.N. Skubitz, Ph.D.
Professor, Department of Laboratory Medicine and Pathology
Adjunct Professor, Dept Obstetrics, Gynecology, and Women's Health
University of Minnesota
MMC 395
420 Delaware Street, S.E.
Minneapolis, MN  55455
skubi002@umn.edu

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